Custom Blend: Keystone Strains

Learn about the different strains here:

Benefits of Bifidobacterium Infantis

• Infant Gut Microbiome Optimization:

B. infantis is specifically adapted to metabolize human milk oligosaccharides (HMOs), which are complex carbohydrates found in breast milk that human cells cannot digest. It quickly colonizes the infant gut, reducing pathogens and establishing a healthy microbial environment.

• Immune System Development: It aids in training the developing immune system, leading to better immune regulation and potentially improved responses to vaccinations.

• Digestive Health (Infants & Children):
  Supplementation has been shown to reduce symptoms of colic, alleviate irritable bowel syndrome (IBS) symptoms (such as pain and bloating), and decrease the risk of digestive system issues in premature babies.

• Anti-inflammatory Effects: B. infantis produces short-chain fatty acids (SCFAs) like butyrate, which strengthen the gut barrier and reduce intestinal inflammation. This is particularly beneficial for infants with severe acute malnutrition or those with high levels of intestinal inflammation.

• Weight Gain Support: Studies have shown that B. infantis can improve weight gain in malnourished infants by enhancing nutrient absorption.

Benefits of L. Casei:

• Digestive Health & Regularity: L. casei aids in breaking down nutrients, maintaining gut barrier function, and relieving constipation. It has been shown to reduce symptoms in patients with irritable bowel syndrome and chronic constipation, including in patients with Parkinson's disease.

• Immune System Modulation: It helps boost the immune system by stimulating immune cells and fighting off pathogenic bacteria, particularly in the gastrointestinal tract.

• Antibiotic-Associated Diarrhea: Studies suggest it can reduce the incidence of diarrhea associated with antibiotic use.

• Gut-Brain Axis & Mental Health: L. casei
  Shirota may help modulate neurotransmitters like serotonin and dopamine, potentially improving mood and reducing anxiety.

• Inflammation & Chronic Illness: It has shown potential in decreasing pro-inflammatory cytokines, reducing blood pressure, and managing dyslipidemia.

• Skin Health: Some evidence suggests it may improve skin hydration and reduce eczema symptoms.

Benefits of L. Gasseri 

• Weight Management and Fat Loss: Studies indicate that L. gasseri (particularly strains SBT2055 and BNR17) helps reduce abdominal fat, body weight, and waist circumference in as little as 12 weeks. It works by modulating gut microbiota, reducing fat absorption, and influencing metabolism.

• Digestive Health and IBS: L. gasseri is effective at improving gut health, reducing bloating, managing constipation, and relieving symptoms of irritable bowel syndrome (IBS), especially abdominal pain.

• Vaginal Health: As a core component of the vaginal microbiota, this bacteria helps prevent bacterial vaginosis, fights infections, and may help lower the risk of HPV.

• Immune System Modulation: It helps boost immunity by increasing T-cell production, reducing inflammation, and potentially improving allergic symptoms.

• Metabolic Health and Stress Reduction: Some studies suggest it can reduce cholesterol levels and alleviate stress-related physical or mental symptoms.

Lactobacillus Crispatus 

Lactobacillus crispatus may be microscopic, but its impact on vaginal health is enormous. It’s a rod-shaped, lactic acid–producing bacteria commonly found in both the vaginal microbiome and gastrointestinal tract. Among the many types of vaginal bacteria, L. crispatus is considered a dominant and protective member of a healthy vaginal microbiome. The presence of Lactobacillus crispatus isn’t just helpful, it’s often essential for long-term vaginal health.

By producing lactic acid, Lactobacillus crispatus maintains a vaginal pH that is typically below 4.5. This acidic environment helps prevent the growthand attachment of vaginal pathogens, such as Gardnerella vaginalis, the primary cause of bacterial vaginosis (BV). Alongside lactic acid, it produceshydrogen peroxide and bacteriocins — natural antimicrobial agents that can kill or inhibit the growth of both bacteria and fungi, including Candida albicans.

Interaction with vaginal epithelial cells

Beyond its effects on the microbiome, Lactobacillus crispatus plays a role in maintaining vaginal health thanks to a direct relationship with the cells that line the vaginal wall (vaginal epithelial cells). It can actually form a biofilm of its own, which prevents other pathogenic biofilms from forming. 

This species plays a crucial role in maintaining a strong mucosal barrier by producing metabolites that promote vaginal epithelial health and integrity. It also prevents pathogens from adhering to these cells, which is a critical first step in infection. In laboratory and animal models, Lactobacillus crispatus has been shown to enhance gene expression related to immune defense, while simultaneously calming inflammation. It reduces the activation of immune cells like dendritic cells, helping to avoid an overreaction to normal stimuli and keeping the vaginal environment in a more balanced, less inflamed state.

These combined effects help prevent vaginal infections before they start, while supporting comfort and resilience in the vaginal tissue itself.

Bacillus Coagulans 

Bacillus coagulans is a hardy, spore-forming probiotic that survives stomach acid to promote digestive health, specifically alleviating symptoms of IBS (abdominal pain, bloating, diarrhea) and constipation. It enhances immune function, reduces inflammation, improves protein absorption, and may aid in managing rheumatoid arthritis and improving vaginal health. 

Key health benefits include: 

• Digestive Health (IBS and Constipation): Clinical studies show that B. coagulans significantly improves IBS symptoms, including abdominal pain, diarrhea, and constipation. It is effective in normalizing bowel movements and increasing stool consistency.

• Immune System Support: This probiotic acts as an immune modulator, aiding the body's defense against infections, according to RxList. It has been shown to reduce inflammatory markers like C-reactive protein (CRP).

• Enhanced Nutrient Absorption: B. coagulans produces digestive enzymes that assist in breaking down food, which increases the absorption of nutrients and amino acids, specifically when taken with protein.

• Anti-inflammatory and Joint Health: It has demonstrated potential in reducing disability and pain associated with rheumatoid arthritis by acting as an anti-inflammatory agent.

• Vaginal and Oral Health: When used in specific applications, it may assist in treating non-specific vaginitis. It is also being researched for its potential to improve oral health by reducing gingivitis.